Most hormone replacement therapy uses oral form of hormones for treatment. Taken in pill form, they must go through your digestive tract before they can be entirely absorbed by your body. Pellet-based therapy is done by implanting hormones in your skin. Implanting hormone pellets is a simple and non-invasive procedure, typically taking less than five minutes. Essentially, a provider will subcutaneously place hormone pellets in your skin. This subcutaneous placement of hormones allows patients to receive a steady flow of hormones 24/7. This constant flow helps you potentially avoid unwanted side effects.